Schneider Research Group

Our Team

Our Research

We study, develop, and apply novel and useful, catalytic, and highly stereoselective bond-forming processes. They are intended to provide straightforward access to complex and highly valuable chemical structures represented in biologically active natural products and medicinally relevant molecules.

The image shows monomorine, alkaloid (-)-205, thiobinupharidine, and vittatalactone as prominent examples of our natural product synthesis program.

The synthesis of biologically active natural products ...

... underlines the practicality and importance of stereoselective protocols delevoped in our research group.

The image shows a chiral BINOL-based phosphoric acid, a prolinol ether, a palladium-aqua-complex, a rhodium catalyst, a Titanium-based BINOLate, and a bifunctional thiourea utilized successfully in our stereoselective transformations.

Both chiral transition metal complexes and organocatalysts ...

... are designed and applied for the development of new enantio- and diastereoselective reactions.

Overview of transient intermediates utilized by our group, Image: M. Sickert.

In-situ generated and highly reactive ...

... reaction intermediates are converted stereoselectively to highly valuable and complex heterocycles.

The image shows ten nitrogen, oxygen, and sulphur-containing heterocycles characterized by their various grade of complexity.

Oxygen-, nitrogen-, and sulphur-containing heterocycles ...

... are prominent motives in many biologically active compounds and can be formed by our stereoselective methods.

The image shows the scheme of continuous flow process for the synthesis of tetrahydrofurans in front of used flow reactor.

Successful translation of batch to continuous flow processes ...

... is gaining our increased research interest combining both worlds - stereoselectivity with high performance.

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Our Publications

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... chemical compounds for precise drug synthesis

The picture shows the catalysis principle of silylium-ACDC in the polarity reversal strategy of hydrazones
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Good News: New process for polarity inversion of ...

The image shows a collage of the image from the press release and the titled topic on “Pharmaceuticals: New process for reversing the polarity of chemical compounds”
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Chiral 1,4-(hetero)-dicarbonyls via α-carbonyl Umpolung

Figure shows the enantioselective synthesis of 1,4-(hetero)-dicarbonyl compounds by α-carbonyl polarity reversal
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Optically harmonious: ACDC with IDPi in 1.4 rhythm

Figure shows the enantioselective synthesis of 1,4-(hetero)-dicarbonyl compounds by α-carbonyl polarity reversal
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... optically active 2,3-Dihydro-1H-pyrrolizin-3-ol

[Translate to English:] Abbildung zeigt die Brønsted-Säure-katalysierte [6 + 2]-Cycloaddition von transienten 2-Methid 2H-Pyrrol mit Aldehyden
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Nice Teamwork: Enol+Pyrrolemethid+H gives easily..

[Translate to English:] Abbildung zeigt die Brønsted-Säure-katalysierte [6 + 2]-Cycloaddition von transienten 2-Methid 2H-Pyrrol mit Aldehyden
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with option: environmentally friendly + resource-efficient

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As practical as Lego: Flexibly linked iCPAs ...

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... C-Ring: via Oxa-Piancatelli

The image shows the organocatalytic enantioselective oxa-Piancatelli rearrangement
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Simply swapped: How an O-ring becomes a ...

The image shows the organocatalytic enantioselective oxa-Piancatelli rearrangement
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(3+2) Annulation of azoalkenes with chiral Pd-enolates

The figure shows an enantioselective (3+2) annulation reaction of ß-keto-esters with azoalkenes to bicyclic dihydropyrroles by cooperative palladium and Brønsted acid catalysis.
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Easy calculation: (1,4)*(3+2) = top e.e.

The figure shows an enantioselective (3+2) annulation reaction of ß-keto-esters with azoalkenes to bicyclic dihydropyrroles by cooperative palladium and Brønsted acid catalysis.
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... the reaction of thioketones with alkynes.

The figure shows the reaction of thioketones with alkynes in a (3+2) cycloaddition.
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Direct Access to 1,3-Oxathiolan-5-ones through ...

The figure shows the reaction of thioketones with alkynes in a (3+2) cycloaddition.
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... simple THC synthesis via asymmetric cyclization

Figure shows the IDPi-catalyzed asymmetric synthesis of cis-tetrahydrocannabinoids
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Thanks IDPi: just in 3 steps to natural products ...

Figure shows the IDPi-catalyzed asymmetric synthesis of cis-tetrahydrocannabinoids
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Positions

The image shows abstractly the view along the third floor highlighting current research topics.

Young Scientists

Are you highly motivated and interested in designing new asymmetric organic transformations, triggered by process development, or fascinated by natural product synthesis? We offer Master and Ph.D. positions any time. Please apply.

If you are interested in working in our group, you can send your application (CV, recommendation, list of publication and presentation) to Prof. C. Schneider by E-mail or postal mail.

Teaching

Here you can find further information about lectures, seminars, and internships and about registration for Bachelor, Master, and Ph.D thesis.

Briefly Explained

In collaboration with our teaching assistent team our short clips of experiments support our digital lectures. (Video in German)

Teaching in the summer semester

"Chemie der organischen Stoffklassen"- "OC-I" (13-111-0331-N)

The course is given in German.

Sommer Semester - for 2nd Semester of Bachelor Chemie: Join the Moodle-course​​ with the key you got by registering for the Module via Almaweb. For further questions, please contact Dr. Marcel Sickert.

„Organische Chemie I” OC-I (13-BCH-0205)

The course is given in German.

Sommer Semester - for 2nd Semester of Bachelor Biochemie: Join the Moodle-course​​ with the key you got by registering for the Module via Almaweb. For further questions, please contact Dr. Marcel Sickert.

Teaching in the winter semester

"Organisch-Chemische Reaktionsmechanismen"- "OC-II" (13-111-0341-N)

The course is given in German.

Winter Semester - for 3rd Semester of Bachelor Chemie: Join the Moodle-course​​ with the key you got by registering for the Module via Almaweb. For further questions, please contact Dr. Marcel Sickert.

„Organisch-chemische Reaktionsmechanismen” OC-II (13-BCH-0310)

The course is given in German.

Winter Semester - for 3rd Semester of Bachelor Biochemie: Join the Moodle-course​​ with the key you got by registering for the Module via Almaweb. For further questions, please contact Dr. Marcel Sickert.

„Stereoselektive Synthesemethoden" (13-121-0317)

Winter Semester 2023/2024 for Master of Chemistry (Choice: 13-121-0317):

Information will become available as soon as the Winter Semester 2023/2024 starts. For questions, please contact Dr. Marcel Sickert.

enlarge the image: The image shows the labs and important glas equipment
Intro for the practical course in organic chemistry. Image: Marcel Sickert

„OC-Grundpraktikum" (13-111-0341-N.P)

The course is given in German. Winter Semester for 3rd Semester of Bachelor Chemie:

Join the Moodle-course​​​​​ with the key you got after passing the OCI-exam. For further questions, please contact Dr. Marcel Sickert.

Contact

Head of the Group

Prof. Dr. Christoph Schneider

Prof. Dr. Christoph Schneider

Professor

Johannisallee 29
04103 Leipzig

Phone: +49 341 97 - 36559
Fax: +49 341 97 - 36599

Secretary

Constanze Müller

Constanze Müller

Sekretariat

Johannisallee 29, Room 160
04103 Leipzig

Telephone: +49 341 97-36529
Telefax: +49 341 97-36599

Our institute is located in the main building of the Faculty of Chemistry and Mineralogy. You can reach us by public transportation (lines 2, 16, 60).

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