Schneider Research Group

Our Team

The photo shows the team of the research group of Prof. C. Schneider nearby the Department of Organic Chemistry - Summer 2022.

Welcome ...

... to the website of the Schneider Research Group. We invite you to to stay and read. In the following we will provide further information about us.

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Head of the Group

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Institute of Organic Chemistry

Secretary

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Our Team - Summer 2022, Photo: Marcel Sickert.

Our Group

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The picture shows a group picture from the autumn symposium of Prof. C. Schneider's working group with alumni in the foyer of the Faculty of Chemistry and Mineralogy at the University of Leipzig

Our last Alumni symposium ...

... took place on 09/17/22. This meeting invited to exchange experiences, to network and simply to sit together. Interested in how the last meeting was, who presented and when the next meeting is?

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Our Research

We study, develop, and apply novel and useful, catalytic, and highly stereoselective bond-forming processes. They are intended to provide straightforward access to complex and highly valuable chemical structures represented in biologically active natural products and medicinally relevant molecules.

The image shows monomorine, alkaloid (-)-205, thiobinupharidine, and vittatalactone as prominent examples of our natural product synthesis program.

The synthesis of biologically active natural products ...

... underlines the practicality and importance of stereoselective protocols delevoped in our research group.

The image shows a chiral BINOL-based phosphoric acid, a prolinol ether, a palladium-aqua-complex, a rhodium catalyst, a Titanium-based BINOLate, and a bifunctional thiourea utilized successfully in our stereoselective transformations.

Both chiral transition metal complexes and organocatalysts ...

... are designed and applied for the development of new enantio- and diastereoselective reactions.

Overview of transient intermediates utilized by our group, Image: M. Sickert.

In-situ generated and highly reactive ...

... reaction intermediates are converted stereoselectively to highly valuable and complex heterocycles.

The image shows ten nitrogen, oxygen, and sulphur-containing heterocycles characterized by their various grade of complexity.

Oxygen-, nitrogen-, and sulphur-containing heterocycles ...

... are prominent motives in many biologically active compounds and can be formed by our stereoselective methods.

The image shows the scheme of continuous flow process for the synthesis of tetrahydrofurans in front of used flow reactor.

Successful translation of batch to continuous flow processes ...

... is gaining our increased research interest combining both worlds - stereoselectivity with high performance.

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Our Publications

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... simple THC synthesis via asymmetric cyclization

Figure shows the IDPi-catalyzed asymmetric synthesis of cis-tetrahydrocannabinoids
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Thanks IDPi: A good mood in just 3 steps ...

Figure shows the IDPi-catalyzed asymmetric synthesis of cis-tetrahydrocannabinoids
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... by cooperative Palladium and Brønsted Acid Catalysis.

The figure shows enantioselective 1,6-addition of β-ketoesters to in situ generated para-quinone methides by palladium/Brønsted acid cooperative catalysis
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Excellent Deal: Two activated for the price of one ...

The figure shows enantioselective 1,6-addition of β-ketoesters to in situ generated para-quinone methides by palladium/Brønsted acid cooperative catalysis
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Strong H-bond donors in catalysis

The image shows super-acidic and confined Brønsted acid catalysts: imidodiphosphates (IDPs), Imino-Imidodiphosphates (iIDPs), Imidodiphosphorimidates, Disulfonimides (DSIs), Chiral BINSA-ammonium salts (Review).
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Super-acidic and highly selective

The image shows super-acidic and confined Brønsted acid catalysts: imidodiphosphates (IDPs), Imino-Imidodiphosphates (iIDPs), Imidodiphosphorimidates, Disulfonimides (DSIs), Chiral BINSA-ammonium salts (Review).
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... allows access to cyclopenta[b]pyrrols

The image shows the enantioselective [6 + 2]-cycloaddition of transient 3-methide-3H-pyrroles with 2-vinylindoles under vhiral Brønsted acid catalysis
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Top organized networking ...

The image shows the enantioselective [6 + 2]-cycloaddition of transient 3-methide-3H-pyrroles with 2-vinylindoles under vhiral Brønsted acid catalysis
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One chip, two catalysts = many opportunities in no time

The image shows the principle of Lab-on-chip where two different stereoselective reaction were proceeded utilizing chiral heterogonous organocatalysts. The products were analysed continuously on the chip for optical activity and identity.
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Pretty easy to count: 1, 2, many

The image shows the principle of Lab-on-chip where two different stereoselective reaction were proceeded utilizing chiral heterogonous organocatalysts. The products were analysed continuously on the chip for optical activity and identity.
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... 3 {d.r., e.r., polycyclic}

The image shows the enantioselective annulation of α,β-unsaturated N-acyliminium ions with β-keto ester enolates via cooperative palladium/Brønsted acid catalysis.
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Simple Math: (1+2)*(1,4) = ...

The image shows the enantioselective annulation of α,β-unsaturated N-acyliminium ions with β-keto ester enolates via cooperative palladium/Brønsted acid catalysis.
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Enantioselective Allenylation by Cooperative Catalysis

The image shows the cooperative Palladium/Brønsted acid catalysis towards the highly enantioselective allenylation of ß-keto esters
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Our (Synfact) Highlight: Palladium "Sw{e.e.}t-and-Sour"

The image shows the cooperative Palladium/Brønsted acid catalysis towards the highly enantioselective allenylation of ß-keto esters
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Overview about asymmetric cycloadditions of methides

The image shows Asymmetric Brønsted Acid-Catalyzed Cycloadditions of Ortho-Quinone Methides and Related Compounds (Review).
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More than just team-building - Activities from 2018 to 2021

The image shows Asymmetric Brønsted Acid-Catalyzed Cycloadditions of Ortho-Quinone Methides and Related Compounds (Review).
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Positions

The image shows abstractly the view along the third floor highlighting current research topics.

Young Scientists

Are you highly motivated and interested in designing new asymmetric organic transformations, triggered by process development, or fascinated by natural product synthesis? We offer Master and Ph.D. positions any time. Please apply.

If you are interested in working in our group, you can send your application (CV, recommendation, list of publication and presentation) to Prof. C. Schneider by E-mail or postal mail.

Teaching

Here you can find further information about lectures, seminars, and internships and about registration for Bachelor, Master, and Ph.D thesis.

The picture shows the award winners (Dr. Marcel Sickert, 2nd from right) for special commitment in teaching 2020/2021 together with Prof. R. Gläser (centre) Vice President for Talent Development: Studies and Teaching.

We stand for excellent teaching!

Dr. Marcel Sickert (2.f.l.) was awarded the "Main Prize for Teaching" as part of the celebration of the university society "Freunde und Förderer der Universität Leipzig e.V." on December 2nd, 2022 in the Audimax of the University of Leipzig.

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The image shows the working principle of a Dean-Stark set up explained by Prof. C. Schneider.

Actual Lectures, Seminares, and Practical Courses

Information about our teaching modules 13-231-0331.VL01 and 13-111-0341-N.PR01 are deposited in our Moodle courses.

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The image shows a collage assembling pictures of a running reaction on the left side, a reaction control by TLC, NMR and HPLC spectra on the right side.

Internships

Please contact Dr. M. Sickert for the application of Bachelor- and Project theses.

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The image shows abstractly the view along the third floor highlighting current research topics.

Master, Ph.D., and PostDoc Positions

Interested in Master, Ph.D. or PostDoc positions in our research group? Please contact Prof. C. Schneider directly.

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Briefly Explained

In collaboration with our teaching assistent team our short clips of experiments support our digital lectures. (Video in German)

Teaching in the summer semester

„Highlights in Natural Products Synthesis" (13-122-0321)

Summer Semester 2022 for Master Chemie (Choice: 13-122-0321):

Information will become available as soon as the Summer Semester 2022 starts. For questions, please contact Dr. Marcel Sickert.

Teaching in the winter semester

„Stereoselektive Synthesemethoden" (13-121-0317)

Winter Semester 2022/2023 for Master of Chemistry (Choice: 13-121-0317):

Information will become available as soon as the Winter Semester 2022/2023 starts. For questions, please contact Dr. Marcel Sickert.

enlarge the image: The image shows the labs and important glas equipment
Intro for the practical course in organic chemistry. Image: Marcel Sickert

„OC-Grundpraktikum" (13-111-0341-N.P)

The course is given in German. Winter Semester 2021/2022 for 3th Semester of Bachelor Chemie:

Join the Moodle-course​​​​​ with the key you got after passing the OCI-exam. For further questions, please contact Dr. Marcel Sickert.

ESF-Junior Research Group

Funded by European Social Fund and by the „Sächsische Aufbaubank" young scientists are trained on the promising technology field „Heterogeneously Catalysed Synthetic Processes in Flow Systems" (01 Jan. 2020 – 31 Dec. 2022) throughout their doctorates.

The image shows all working areas of all four research groups.

Interdisciplinary collaboration ...

... from four research groups of the University of Leipzig uniting the working areas of organic, analytical, chemical technology, and physical chemistry.

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Contact

Head of the Group

Prof. Dr. Christoph Schneider

Prof. Dr. Christoph Schneider

Professor

Johannisallee 29
04103 Leipzig

Phone: +49 341 97-36559
Fax: +49 341 97-36599

Secretary

Constanze Müller

Constanze Müller

Sekretariat

Johannisallee 29, Room 160
04103 Leipzig

Telephone: +49 341 97-36529
Telefax: +49 341 97-36599

Our institute is located in the main building of the Faculty of Chemistry and Mineralogy. You can reach us by public transportation (lines 2, 16, 60).

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