Die Forschungsergebnisse der von Mitarbeiterinnen und Mitarbeitern bearbeiteten Projekte werden in internationalen peer-review Journalen veröffentlicht und in der Forschungsgemeinschaft beachtet und zitiert.

Unsere Publikationsliste

  • V. Riedl, M. Portius, L. Heiser, P. Riedl, T. Jakob, R. Gehring, T. Berg, T. Pompe
    Development of a Synthesis Strategy for Sulfamethoxazole Derivatives for the Coupling to Hydrogel Microparticles
    J. Mater. Chem. B 2023, Accepted Manuscript.
    Zur Publikation
  • J. Liu, S. Mallick, Y. Xie, C. Grassin, B. Lucas, B. Schölermann, A. Pahl, R. Scheel, C. Strohmann, C. Protzel, T. Berg, C. Merten, S. Ziegler, H. Waldmann
    Morphological profiling identifies the motor protein Eg5 as cellular target of spirooxindoles
    Angew. Chem. Int. Ed. 2023, e202301955.
    Zur Publikation
  • F. Nietzold, S. Rubner, B. Labuzek, P. Golik, E. Surmiak, X. del Corte, R. Kitel, C. Protzel, R. Reppich‐Sacher, J. Stichel, K. Magiera-Mularz, T. A. Holak, T. Berg
    Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group
    ChemBioChem 2023, 24, e202300006.
    Zur Publikation
  • K. S. Eckhardt, T. Münzel, J. Gräb, T. Berg
    Stafiba: a STAT5-selective small-molecule inhibitor
    ChemBioChem 2023, 24, e202200553.
    Zur Publikation
  • A. Berg, M. Gräber, S. Schmutzler, R. Hoffmann, T. Berg
    A High-Throughput Fluorescence Polarization-Based Assay for the SH2 Domain of STAT4
    Methods Protoc. 2022, 5, 93.
    Zur Publikation
  • J. Brauer, M. Mötzing, C. Gröst, R. Hoffmann, T. Berg
    Templated generation of a Bcl-xL inhibitor by isomer-free SPAAC based on azacyclonon-5-yne
    Chem. Eur. J. 2022, 28, e202202259.
    Zur Publikation
  • D. Müller-Klieser, T. Berg
    Asymmetrically Substituted m-Terphenyl Phosphates Inhibit the Transcription Factor STAT5a
    ChemBioChem 2022, 23, e202100603.
    Zur Publikation
  • L. Kolano, D. Knappe, A. Berg, T. Berg, R. Hoffmann
    Effect of amino acid substitutions on 70S ribosomal binding, cellular uptake, and antimicrobial activity of oncocin Onc112
    ChemBioChem 2022, 23, e202100609.
    Zur Publikation
  • J. Gräb, T. Berg
    The selectivity of fosfosal for STAT5b over STAT5a is mediated by Arg566 in the linker domain
    ChemBioChem 2020, 21, 2264-2267.
    Zur Publikation
  • K. Natarajan, D. Müller-Klieser, S. Rubner, T. Berg
    Stafia-1: a STAT5a-selective inhibitor developed via docking-based screening of in silico O-phosphorylated fragments
    Chem. Eur. J. 2020, 26, 148-154.
    Zur Publikation
  • F. Nietzold, S. Rubner, T. Berg
    The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a
    Chem. Commun. 2019, 55, 14351-14354.
    Zur Publikation
  • A. Berg, B. Sperl, T. Berg
    ATP inhibits the transcription factor STAT5b
    ChemBioChem 2019, 20, 2227-2231 ("Very Important Paper").
    Zur Publikation
  • C. Lis, T. Berg
    Synthesis of TRIPCO: A New Cyclooctyne for iSPAAC
    Synlett 2019, 30, 939-942.
    Zur Publikation
  • J. Gräb, A. Berg, L. Blechschmidt, B. Klüver, S. Rubner, D. Y. Fu, J. Meiler, M. Gräber, and T. Berg
    The STAT5b linker domain mediates the selectivity of catechol bisphosphates for STAT5b over STAT5a
    ACS Chem. Biol. 2019, 14, 796-805.
    Zur Publikation
  • S. Rubner, S. Schubert, and T. Berg
    Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells
    Org. Biomol. Chem. 2019, 17, 3113-3117.
    Zur Publikation
  • S. Abdelfatah, A. Berg, Q. Huang, L. J. Yang, S. Hamdoun, A. Klinger, H. J. Greten, E. Fleischer, T. Berg, V. K. W. Wong, T. Efferth
    MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
    Acta Pharm. Sin. B 2019, 9, 1021-1034.
    Zur Publikation
  • S. Rubner, A. Scharow, S. Schubert, T. Berg
  • Selective degradation of polo‐like kinase 1 by a hydrophobically tagged inhibitor of the polo‐box domain
  • Angew. Chem. Int. Ed. 2018, 57, 17043-17047.
  • Zur Publikation
  • C. Lis, S. Rubner, C. Gröst, R. Hoffmann, D. Knappe, T. Berg
    iSPAAC: isomer‐free generation of a Bcl‐xL‐inhibitor in living cells
    Chem. Eur. J. 2018, 24, 13762-13766.
    Zur Publikation
  • C. Lis, S. Rubner, M. Roatsch, A. Berg, T. Gilcrest, D. Fu, E. Nguyen, A.-M. Schmidt, H. Krautscheid, J. Meiler, T. Berg
    Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells
    Sci. Rep. 2017, 7, 17390.
    Zur Publikation
  • T. Berg
    Inhibition of Protein-Protein Interactions: New Options for Developing Drugs against Neglected Tropical Diseases
    Angew. Chem. Int. Ed. 2017, 56, 12048-12050.
    Zur Publikation
  • A. Berg, T. Berg
    A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b
    Bioorg. Med. Chem. Lett. 2017, 27, 3349-3352.
    Zur Publikation
  • N. Elumalai, K. Natarajan, T. Berg
    Halogen-substituted catechol bisphosphates are potent and selective inhibitors of the transcription factor STAT5b
    Bioorg. Med. Chem. 2017, 25, 3871-3882.
    Zur Publikation
  • N. Elumalai, A. Berg, S. Rubner, L. Blechschmidt, C. Song, K. Natarajan, J. Matysik, T. Berg
    Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b.
    Sci. Rep. 2017, 7, 819.
    Zur Publikation
  • T. Berg
    Protein-Protein-Wechselwirkungen mit organischen Substanzen hemmen.
    Nachr. Chem. 2016, 64, 960-964.
    Zur Publikation
  • T. Goldbach, D. Knappe, C. Reinsdorf, T. Berg, R. Hoffmann
    Ribosomal binding and antibacterial activity of ethylene glycol-bridged apidaecin Api137 and oncocin Onc112 conjugates.
    J. Pept. Sci. 2016, 22, 592-599.
    Zur Publikation
  • A. Scharow, D. Knappe, W. Reindl, R. Hoffmann, T. Berg
    Development of bifunctional inhibitors of polo-like kinase 1 with low nanomolar activities against the polo-box domain.
    ChemBioChem 2016, 17, 759-767.
    Zur Publikation
  • A. Berg, T. Berg
    Inhibitors of the Polo-Box Domain of Polo-like Kinase 1.
    ChemBioChem 2016, 17, 650-656.
    Zur publikation
  • N. Elumalai, A. Berg, S. Rubner, T. Berg
    Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b
    ACS Chem. Biol. 2015, 10, 2884−2890.
    Zur Publikation
  • A. Scharow, M. Raab, K. Saxena, S. Sreeramulu, D. Kudlinzki, S. Gande, C. Dötsch, E. Kurunci-Csacsko, S. Klaeger, B. Kuster, H. Schwalbe, K. Strebhardt, T. Berg
    Optimized Plk1 PBD inhibitors based on Poloxin induce mitotic arrest and apoptosis in tumor cells.
    ACS Chem. Biol. 2015, 10, 2570-2579.
    Zur Publikation
  • C. Gröst, T. Berg
    PYRROC: the first functionalized cycloalkyne that facilitates isomer-free generation of organic molecules by SPAAC
    Org. Biomol. Chem. 2015, 13, 3866-3870.
    Zur Publikation
  • N. Elumalai, A. Berg, K. Natarajan, A. Scharow, T. Berg
    Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a
    Angew. Chem. Int. Ed. 2015, 54, 4758-4763.
    Zur Publikation
  • D. Cubrilovic, K. Barylyuk, D. Hofmann, M. Walczak, M. Gräber, T. Berg, G. Wider, R. Zenobi
    Direct Monitoring of Protein-Protein Inhibition Using Nano Electrospray Ionization Mass Spectrometry
    Chem. Sci. 2014, 5, 2794-2803.
    Zur Publikation
  • C. Gröst, M. Gräber, M. Hell, T. Berg
    Synthesis and biochemical evaluation of highly enantiomerically pure (R,R)- and (S,S)-alexidine.
    Bioorg. Med. Chem. 2013, 21, 7357-7363.
    Zur Publikation
  • M. Gräber#, M. Hell#, C. Gröst#, A. Friberg, B. Sperl, M. Sattler, T. Berg
    Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.
    Angew. Chem. Int. Ed. 2013, 52, 4487-4491 („Hot paper“).
    Zur Publikation
  • T. Berg
    Reply to „Revisiting the specificity of small-molecule inhibitors: the example of Stattic in dendritic cells”.
    Chem. Biol. 2012, 19, 1215-1216.
    Zur Publikation
  • T. Itkin, A. Ludin, B. Gradus, S. Gur-Cohen, A. Kalinkovich, A. Schajnovitz, Y. Ovadya, O. Kollet, J. Canaani, E. Shezen, D.J. Coffin, G.N. Enikolopov, T. Berg, W. Piacibello, E. Hornstein, T. Lapidot
    FGF-2 Expands Murine Hematopoietic Stem and Progenitor Cells via Proliferation of Stromal Cells, c-Kit Activation and CXCL12 Downregulation
    Blood 2012, 120, 1843-1855.
    Zur Publikation
  • F. Liu, J.-E. Park, W-J. Qian, D. Lim, A. Scharow, T. Berg, M.B. Yaffe, K.S Lee, T.R. Burke
    Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1
    ChemBioChem 2012, 13, 1291-1296.
    Zur Publikation
  • F. Liu, J.-E. Park, W-J. Qian, D. Lim, A. Scharow, T. Berg, M.B. Yaffe, K.S Lee, T.R. Burke
    Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-based Diversification.
    ACS Chem. Biol. 2012, 7, 805-810.
    Zur Publikation
  • M. Sanhaji, N-N. Kreis, B. Zimmer, T. Berg, F. Louwen, J. Yuan
    p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.
    Cell Cycle 2012, 11, 543-553.
    Zur Publikation
  • A. Hollis, B. Sperl, M. Gräber, T. Berg
    The natural product betulinic acid inhibits C/EBP family transcription factors.
    ChemBioChem 2012, 13, 302-307.
    Zur Publikation
  • W. Reindl, K. Strebhardt, T. Berg
    A Fluorescence Polarization Assay for the Discovery of Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1.
    Meth. Mol. Biol. 2012, 795, 69-81, published online.
    Zur Publikation
  • J. Yuan, M. Sanhaji, A. Krämer, W. Reindl, M. Hofmann, N.N. Kreis, B. Zimmer, T. Berg, K. Strebhardt
    Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo.
    Am. J Pathol. 2011 , 179, 2091 - 2099.
    Zur Publikation
  • M. Gräber, W. Janczyk, B. Sperl, N. Elumalai, C. Kozany, F. Hausch, T.A. Holak, T. Berg
    Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives.
    ACS Chem. Biol. 2011, 6, 1008 - 1014.
    Zur Publikation
  • F. Liu, J.E. Park, W.J. Qian, D. Lim, M. Gräber, T. Berg, M.B. Yaffe, K.S. Lee, T.R. Burke, Jr.
    Serendipitious alkylation of a Plk1 ligand uncovers a new binding channel.
    Nat. Chem. Biol. 2011, 7, 595-601.
    Zur Publikation
  • S. Richter, I. Neundorf, K. Loebner, M. Gräber, T. Berg, R. Bergmann, J. Steinbach, J. Pietzsch, F. Wuest
    Phosphopeptides with improved cellular uptake properties as ligands for the polo-box domain of polo-like kinase 1. Bioorg.
    Med. Chem. Lett. 2011, 21, 4686-4689.
    Zur Publikation
  • T. Berg
    Small-Molecule Modulators of c-Myc/Max and Max/Max Interactions.
    Curr. Top. Microbiol. Immunol. 2011, 348, 139-149.
    Zur Publikation
  • S. Wetzel, W. Wilk, S. Chammaa, B. Sperl, A. Roth, A. Yektaoglu, S. Renner, T. Berg, C. Arenz, A. Giannis, T.I. Oprea, D. Rauh, M. Kaiser, H. Waldmann
    A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of gamma-Pyrones.
    Angew. Chem. Int. Ed. 2010, 49, 3666-3670.
    Zur Publikation
  • D. Castelletti, G. Fiaschetti, V. Di Dato, U. Ziegler, C. Kumps, K. De Preter, M. Zollo, F. Speleman, T. Shalaby, D. De Martino, T. Berg, A. Eggert, A. Arcaro, M.A. Grotzer
    The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors.
    Mol. Cancer Ther. 2010, 9, 3145-3157.
    Zur Publikation
  • T. Berg
    Small-molecule inhibitors of protein–protein interactions.
    In: Protein-protein complexes: Analysis, Modeling and Drug Design (Editor: Martin Zacharias), Imperial College Press, 2010, 318-339.
  • A. Riechers, A. Grauer, S. Ritter, B. Sperl, T. Berg, B. König
    Binding of phosphorylated peptides and inhibition of their interaction with disease-relevant human proteins by synthetic metal-chelate receptors.
    J. Mol. Recognit. 2010, 23, 329-334.
    Zur Publikation
  • W. Reindl, M. Gräber, K. Strebhardt, T. Berg
    Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3.
    Anal. Biochem. 2009, 395, 189-194.
    Zur Publikation
  • B. Sperl, M.H.J. Seifert, T. Berg
    Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.
    Bioorg. Med. Chem. Lett. 2009, 19, 3305-3309.
    Zur Publikation
  • W. Reindl, J. Yuan, A. Krämer, K. Strebhardt, T. Berg
    A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases arrests Cancer Cells in Mitosis.
    ChemBioChem 2009, 10, 1145-1148.
    Zur Publikation
  • T. Berg
    Allosteric switches: remote controls for proteins.
    Angew. Chem. Int. Ed. 2009, 48, 3218-3220.
    Zur Publikation
  • T. Berg
    Modulation of protein–protein interactions with small molecules.
    In: Wiley encyclopedia of chemical biology, volume 4, John Wiley & Sons (Editor: Tadhg P. Begley), 2008, 121-143.
  • W. Reindl, K. Strebhardt, T. Berg
    A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1.
    Anal. Biochem. 2008, 383, 205-209.
    DOI: 10.1016/j.ab.2008.08.014
  • T. Berg
    Small-molecule inhibitors of protein-protein interactions.
    Curr. Opin. Drug Discov. Devel. 2008, 11, 666-674. BioMedCentral
  • T. Berg
    Inhibition of transcription factors with small organic molecules.
    Curr. Opin. Chem. Biol. 2008, 12, 464-471.
    DOI: 10.1016/j.cbpa.2008.07.023
  • T. Berg
    Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules.
    ChemBioChem 2008, 9, 2039-2044.
    DOI: 10.1002/cbic.200800274
  • W. Reindl, J. Yuan, A. Krämer, K. Strebhardt, T. Berg
    Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions.
    Chem. Biol. 2008,15, 459-466.
    DOI: 10.1016/j.chembiol.2008.03.013
    This article was highlighted by:
    1) K.S. Lee, J.R. Idle Pinning down the polo-box domain
    Chem. Biol. 2008, 15, 415-416.
    DOI: 10.1016/j.chembiol.2008.04.009
    2) Faculty of 1000 Biology
  • J. Müller, J. Schust, T. Berg
    A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization.
    Anal. Biochem. 2008, 375, 249-254.
    DOI: 10.1016/j.ab.2008.01.017
  • J. Müller, B. Sperl, W. Reindl, A. Kiessling, T. Berg
    Chromone-based inhibitors of the transcription factor STAT5.
    ChemBioChem 2008, 9, 723-727.
    DOI: 10.1002/cbic.200700701
  • A. Kiessling, R. Wiesinger, B. Sperl, T. Berg
    Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]pyrimidine.
    ChemMedChem 2007, 2, 627-630.
    DOI: 10.1002/cmdc.200600294
  • J. Schust, B. Sperl, A. Hollis, T.U. Mayer, T. Berg
    Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
    Chem. Biol. 2006, 13, 1235-1242.
    DOI: 10.1016/j.chembiol.2006.09.018
    This article was highlighted by:
    1) J.S. McMurray
    A New Small-Molecule STAT3 Inhibitor. Chem. Biol. 2006, 13, 1123-1124
    DOI: 10.1016/j.chembiol.2006.11.001
    2) Faculty of 1000 Biology
  • A. Kiessling, B. Sperl, A. Hollis, D. Eick, T. Berg
    Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules.
    Chem. Biol. 2006, 13, 745-751.
    DOI: 10.1016/j.chembiol.2006.05.011
  • T. Berg
    Inhibition of TNF-a signaling: divide and conquer.
    ChemMedChem 2006,1, 687-688.
    DOI: 10.1002/cmdc.200600050
  • T. Berg, T.U. Mayer, R. Frank
    Trendbericht „Chemische Biologie“ im Gebiet „Biochemie und Molekularbiologie“ 2005.
    Nachr. Chem. 2006, 54, 265-270.
  • S.K. Knauer, S. Moodt, T. Berg, U. Liebel, R. Pepperkok, R.H. Stauber
    Translocation biosensors to study signal-specific nucleo-cytoplasmic transport, protease activity and protein-protein interactions.
    Traffic 2005, 6, 594-606.
    DOI: 10.1111/j.1600-0854.2005.00298.x
  • T. Berg
    Cellular profiling of small-molecule bioactivities: an alternative tool for chemical biology.
    Angew. Chem. Int. Ed. 2005, 44, 5008-5011.
    DOI: 10.1002/anie.200500721
  • T. Berg
    Protein-Protein Interactions: Methods and Applications.
    ChemBioChem 2005, 6, 446-447 (book review).
  • J. Schust, T. Berg
    A high-throughput fluorescence polarization assay for STAT3.
    Anal. Biochem. 2004, 330, 114-118.
    DOI: 10.1016/j.ab.2004.03.024
  • T. Berg
    Use of “tethering” for the identification of a small molecule which binds to a dynamic hot spot on the interleukin-2 surface.
    ChemBioChem 2004, 5, 1051-1053.
    DOI: 10.1002/cbic.200400054
  • T. Berg
    When chemistry met biology.
    Angew. Chem. Int. Ed. 2004, 43, 3750-3751 (Meeting report).
    DOI: 10.1002/anie.200460998
  • J.S. Iacovoni, S.B. Cohen, T. Berg, P.K. Vogt
    v-Jun targets showing an expression pattern that correlates with the transformed cellular phenotype.
    Oncogene 2004, 23, 5703-5706.
    DOI: 10.1038/sj.onc.1207737
  • T. Berg
    Modulation of protein-protein interactions with small organic molecules.
    Angew. Chem. Int. Ed. 2003, 42, 2462-2481.
    DOI: 10.1002/anie.200200558
  • T. Berg, S.B. Cohen, J. Desharnais, C. Sonderegger, D.J. Maslyar, J. Goldberg, D.L. Boger, P.K. Vogt
    Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts.
    Proc. Natl. Acad. Sci. USA 2002, 99, 3830-3835.
    DOI: 10.1073/pnas.062036999
    This article was highlighted by Faculty of 1000 Biology
  • E. Vogel, N. Jux, J. Dörr, T. Pelster, T. Berg, H.-S. Böhm, F. Behrens, J. Lex, D. Bremm, G. Hohlneicher
    Furan-Based Porphyrins: Tetraoxa[4n+2]porphyrin dications with 18 p-, 22 p-, or 26 p-electron systems.
    Angew. Chem. Int. Ed. 2000, 39, 1101-1104.
    DOI: 10.1002/(SICI)1521-3773(20000317)39:63.0.CO;2-F
  • T. Berg, A. Simeonov, K.D. Janda
    A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA.
    J. Comb. Chem. 1999, 1, 96-100.
    DOI: 10.1021/cc9800125
  • T. Berg, A. Vandersteen, K.D. Janda
    High-throughput synthesis and screening for the discovery of hydrolytic metal complexes.
    Bioorg. Med. Chem. Lett. 1998, 8, 1221-1224.
  • D. Enders, T. Berg, G. Raabe, J. Runsink
    Enantioselective synthesis of a-phosphanyl ketones and 2-phosphanyl alcohols.
    Liebigs. Ann. 1997, 345-361.
    DOI 10.1002/jlac.199719970212
  • D. Enders, T. Berg
    Enantioselective synthesis of 2-phosphino alcohols via phosphinylation of metalated chiral aldehyde hydrazones.
    Synlett 1996, 796-798.
    DOI: 10.1055/s-1996-5519
  • D. Enders, T. Berg, G. Raabe, J. Runsink
    Enantioselektive Synthese von a‑Phosphino­ketonen.
    Helv. Chim. Acta 1996, 79, 118 - 122.
    DOI: 10.1002/hlca.19960790112

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