Die Forschungsergebnisse in den von unserer Mitarbeiterinnen und Mitarbeitern bearbeiteten Projekte werden in internationalen peer-review Journalen veröffentlicht und sind in der Forschungsgemeinschaft beachtet und zitiert.
Publikationen (peer reviewed)
2024
- Modular Chip-Based nanoSFC–MS for Ultrafast Separations
C. Weise, M. Schirmer, M. Polack, A. Korell, H. Westphal, J. Schwieger, R. Warias, S., D. Belder
Anal. Chem. 2024, 96, 34, 13888–13896 - Mass spectrometry coupling of chip-based supercritical fluid chromatography enabled by make-up flow-assisted backpressure regulation
C. Weise, J. Fischer, D. Belder
Anal Bioanal Chem. 2024, 416, 4447–4456 - Exploring Defect-Engineered Metal–Organic Frameworks with 1,2,4-Triazolyl Isophthalate and Benzoate Linkers
S. Chetry, M. F. Lukman, V. Bon, R. Warias, D. Fuhrmann, J. Möllmer, D. Belder, C. S. Gopinath, S. Kaskel, A. Pöppl, H. Krautscheid
Inorg. Chem. 2024, 63, 23, 10843–10853 - Online‐Monitoring of the Enantiomeric Ratio in Microfluidic Chip Reactors Using Chiral Selector Ion Vibrational Spectroscopy
S. Schmahl, F. Horn, J. Jin, H. Westphal, D. Belder, K. R. Asmis
ChemPhysChem. 2024, 25, e202300975 - An LSC approach for tritium determination in gaseous mixtures optimized with respect to handling, reaction parameters and miniaturization towards microfluidic analysis
A. Becker, H. Lippold, J. P. Bäcker, D. Belder, C. Fischer
Radiochimica Acta 2024, 112, 231–237 - High-temperature ultrafast ChipHPLC-MS
C. Weise, H. Westphal, R. Warias, D.Belder
Anal. Bioanal. Chem. 2024, 416, 1023–1031 - Coupling of droplet-on-demand microfluidcs with ESI/MS to study single-cell catalysis
M. van der Loh, M. Schiffmann, M. Polack, K. Wink, D. Belder
RSC Adv. 2024, 14, 25337–25346 - Integration of a recyclable silver substrate for in situ surface-enhanced Raman spectroscopy in digital microfluidics
S. Fehse, A. Das, D. Belder
Chem. Commun. 2024, 60, 8252–8255 - Development of an automated platform for monitoring microfluidic reactors through multi-reactor integration and online (chip-) LC/MS-detection
H. Westphal, S. Schmidt, S. Lama, M. Polack, C. Weise, T. Oestereich, R. Warias, T. Gulder, D. Belder
React. Chem. Eng. 2024, 9, 1739–1750
2023
- scMAR-Seq: a novel workflow for targeted single-cell genomics of microorganisms using radioactive labeling
H. Y. Lo, K. Wink, H. Nitz, M. Kästner, D. Belder, J. A. Müller, A. K. Kaster
mSystems 2023, DOI: doi.org/10.1128/msystems.00998-23 - A monolithic microfluidic probe for ambient mass spectrometry imaging of biological tissues
L. Jiang, M. Polack, X. Li, M. Yang, D. Belder, J. Laskin
Lab Chip 2023, DOI: 10.1039/d3lc00637a - Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/M
C. Thoben, N. T. Hartner, M. Hitzemann, C. R. Raddatz, M. Eckermann, D. Belder, S. Zimmermann
Am. Soc. Mass Spectrom. 2023, 34, 5, 857–868 - Coupling microchip pressure regulators with chipHPLC as a step toward fully portable analysis system
Svensson, C. Weise, H. Westphal, S. Södergren, D. Belder, K. Hjort
Sensors & Actuators: B Chemical 2023, 385, 133732 - Surface-Enhanced Raman Spectroscopic Probing in Digital Microfluidics through a Microspray Hole
A. Das, S. Fehse, M. Polack, R. Panneerselvam, D. Belder
Anal. Chem. 2023, 95, 2, 1262–1272
2022
- Integration of Impedimetric Sensors for In Situ Electrochemical Impedance Spectroscopy in Free-Flow Electrophoresis Applications in Lab-on-Chip Systems
T. Haensch, F. D. Zitzmann, H. G. Jahnke, M. E. Blaha, E. Paternoga, K. Zeitler, D. Belder, A. A. Robitzki
ACS Sens. 2022, 7, 12, 3906–3914 - Analysis of double-emulsion droplets with ESI mass spectrometry for monitoring lipase-catalyzed ester hydrolysis at nanoliter scale
L. Heiligenthal, M. van der Loh, M. Polack, M. E. Blaha, S. Moschütz, A. Keim, N. Sträter, D. Belder
Anal. Bioanal. Chem. 2022, 414, 6977–6987 - An integrated resource-efficient microfluidic device for parallelised studies of immobilised chiral catalysts in continuous flow via miniaturized LC/MS-analysis
H. Westphal, R. Warias, C. Weise, D. Ragno, H. Becker, M. Spanka, A. Massi, R. Gläser, C. Schneider, D. Belder
React. Chem. Eng. 2022, 7, 1936–1944 - On-the-Fly Mass Spectrometry in Digital Microfluidics Enabled by a Microspray Hole: Toward Multidimensional Reaction Monitoring in Automated Synthesis Platform
A. Das, C. Weise, M. Polack, R. D. Urban, B. Krafft, S. Hasan, H. Westphal, R. Warias, S. Schmidt, T. Gulder, D. Belder
J. Am. Chem. Soc. 2022, 144, 23, 10353–10360 - Quantification of Biocatalytic Transformations by Single Microbial Cells Enabled by Tailored Integration of Droplet Microfluidics and Mass Spectrometry
K. Wink, M. van der Loh, N. Hartner, M. Polack, C. Dusny, A. Schmid, D. Belder
Angew. Chem. Int. Ed. 2022, 61, e202204098 - Fluorescence lifetime activated droplet sorting (FLADS) for label-free sorting of Synechocystis sp. PCC6803
M. E. Blaha, S. Hasan, C. Dusny, D. Belder
Lab Chip 2022, 22, 1604–1614 Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?
R. Panneerselvam, H. Sadat, E. M. Höhn, A. Das, H. Noothalapati, D. Belder
Lab Chip 2022, 22, 665–682- Multielectrode biosensor chip for spatial resolution screening of 3D cell models based on microcavity arrays
F. D. Zitzmann, S. Schmidt, M. Naumann, D. Belder, H. G. Jahnke, A. A. Robitzki
Biosensors and Bioelectronics 2022, 202, 114010 - Two-photon fluorescence lifetime for label-free microfluidic droplet sorting
S. Hasan, M. E. Blaha, S. K. Piendl, A. Das, D. Geissler, D. Belder
Anal. Bioanal. Chem. 2022, 414, 721–730
2021
- Coupling Droplet Microfluidics with Ion Mobility Spectrometry for Monitoring Chemical Conversions at Nanoliter Scale
N. T. Hartner, K. Wink, C. R. Raddatz, C. Thoben, M. Schirmer, S. Zimmermann, D. Belder
Anal. Chem. 2021, 93, 40, 13615–13623 - Unveiling Organocatalysts Action–Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology
H. Westphal, R. Warias, H. Becker, M. Spanka, D. Ragno, R. Gläser, C. Schneider, A. Massi, D. Belder
ChemCatChem 2021, 13, 5089–5096 - Integration of Segmented Microflow Chemistry and Online HPLC/MS Analysis on a Microfluidic Chip System Enabling Enantioselective Analyses at the Nanoliter Scale
S. K. Piendl, T. Schönfelder, M. Polack, L. Weigelt, T. van der Zwaag, T. Teutenberg, E. Beckert, D. Belder
Lab Chip 2021, 21, 2614–2624 - On-chip Mass Spectrometric Analysis in Non-polar Solvents by Liquid Beam Infrared Matrix-Assisted Laser Dispersion/Ionization
R. D. Urban, T. G. Fischer, A. Charvat, K. Wink, B. Krafft, S. Ohla, K. Zeitler, B. Abel, D. Belder
Anal. Bioanal. Chem. 2021, 413, 1561–1570 - Microfluidic device for concentration and SERS‐based detection of bacteria in drinking water
B. Krafft, A. Tycova, R. D. Urban, C. Dusny, D. Belder
Electrophoresis 2021, 42, 86–94
2020
- On-Line Coupling of Chip-Electrochromatography and Ion Mobility Spectrometry
N. T. Hartner, C. R. Raddatz, C. Thoben, S. K. Piendl, S. Zimmermann, D. Belder
Anal. Chem. 2020, 92, 15129–15136 - How electrospray potentials can disrupt droplet microfluidics and how to prevent this
A. J. Peretzki, S. Schmidt, E. Flachowsky, A. Das, R. F. Gerhardt, D. Belder
Lab Chip, 2020, 20, 4456–4465 - In situ monitoring of photocatalyzed isomerization reactions on a microchip flow reactor by IR-MALDI ion mobility spectrometry
C. Prüfert, R. D. Urban, T. G. Fischer, J. Villatoro., D. Riebe., T. Beitz., D. Belder, K. Zeitler, H. G. Löhmannsröben
Anal. Bioanal. Chem. 2020, 412, 7899–7911 - Conversion Efficiencies of a Few Living Microbial Cells Detected at a High Throughput by Droplet-Based ESI-MS
M. Schirmer, K. Wink, S. Ohla, D. Belder, A. Schmid, C. Dusny
Anal. Chem. 2020, 92, 15, 10700–10708 - A visible‐light‐powered polymerization method for the immobilization of enantioselective organocatalysts into microreactors
R. Warias, D. Ragno, A. Massi, D. Belder
Chem. Eur. J. 2020, 26, 13152–13156 - Multiple Heart-Cutting Two-Dimensional Chip-HPLC Combined with Deep-UV Fluorescence and Mass Spectrometric Detection
S. K. Piendl, D. Geissler, L. Weigelt, D. Belder
Anal. Chem. 2020, 92, 3795–3803 - Unravelling the Configuration of Transient ortho-Quinone Methides by Combining Microfluidics with Gas Phase Vibrational Spectroscopy
M. Mayer , M. Pahl , M. Spanka , M. Grellmann , M. Sickert , C. Schneider , K. R. Asmis, D. Belder
Phys. Chem. Chem. Phys. 2020, 22, 4610–4616 - A microfluidic device enabling surface-enhanced Raman spectroscopy at chip-integrated multifunctional nanoporous membranes
B. Krafft, R. P. Selvam, D. Geissler, D. Belder
Anal. Bioanal. Chem. 2020, 412, 267–277 - On-chip integration of normal phase high-performance liquid chromatography and droplet microfluidics introducing ethylene glycol as polar continuous phase for the compartmentalization of n-heptane eluents
A. J. Peretzki, D. Belder
J. Chromatogr. A 2020, 1612, 460653
2019
- Raman Spectroscopic Detection in Continuous Micro-Flow Using a Chip-Integrated Silver Electrode as Electrically Regenerable SERS Substrate
E. M. Höhn, R. Panneerselvam, A. Das, D. Belder
Anal. Chem. 2019, 91, 9844–9854 - 2D in Seconds: Coupling of Chip-HPLC with Ion Mobility Spectrometry
S. K. Piendl, C. R. Raddatz, N. T. Hartner, C. Thoben, R. Warias, S. Zimmermann, D. Belder
Anal. Chem. 2019, 91, 7613–7620 - Non-aqueous micro free-flow electrophoresis for continuous separation of reaction mixtures in organic media
B. M. Rudisch, S. A. Pfeiffer, D. Geissler, E. Speckmeier, A. A. Robitzki, K. Zeitler, D. Belder
Anal. Chem. 2019, 91, 6689–6694 - Supercritical fluid chromatography on-chip with two-photon excited fluorescence detection for high-speed chiral separations
J. J. Heiland, D. Geissler, S. K. Piendl, R. Warias, D. Belder
Anal. Chem. 2019, 91, 6134–6140 - Large‐Ring Cyclodextrins as Chiral Selectors for Enantiomeric Pharmaceuticals
C. Sonnendecker, S. Th[1]ürmann, C. Przybylski, F. D. Zitzmann, N. Heinke, Y. Krauke, K. Monks, A. A. Robitzki, D. Belder, W. Zimmermann
Angew. Chem. Int. Ed. 2019, 58, 6411–6414 - Joining Microfluidics with Infrared Photodissociation: Online Monitoring of Isomeric Flow-Reaction Intermediates
M. Pahl, M. Mayer, M. Schneider, D. Belder, K. R. Asmis
Anal Chem. 2019, 91, 3199–3203 - Fluorescence lifetime-activated droplet sorting in microfluidic chip systems
S. Hasan, D. Geissler, K. Wink, A. Hagen, J. J. Heiland, D. Belder
Lab Chip 2019, 19, 403–409
2018
- An integrated lab‐on‐a‐chip approach to study heterogeneous enantioselective catalysts at the microscale
R. Warias, A. Zaghi, J. J. Heiland, S. K. Piendl, K. Gilmore, P. H. Seeberger, A. Massi, D. Belder
ChemCatChem. 2018, 10, 5382–5385 - An integrated chip-mass spectrometry and epifluorescence approach for online monitoring of bioactive metabolites from incubated Actinobacteria in picoliter droplets
K. Wink, L. Mahler, J. R. Beulig, S. K. Piendl, M. Roth, D. Belder
Anal. Bioanal. Chem. 2018, 410, 7679–7687 - Sheathless coupling of microchip electrophoresis to ESI-MS utilising an integrated photo polymerised membrane for electric contacting
T. Scholl, C. Dietze, M. Schmidt, S. Ohla, D. Belder
Anal. Bioanal. Chem. 2018, 410, 5741–5750 - Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria
L. Mahler, K. Wink, R. J. Beulig, K. Scherlach, M. Tovar, E. Zang, K. Martin, C. Hertweck, D. Belder, M. Roth
Scientific reports 2018, 8, 13087 - Analyte and matrix evaporability–key players of low-temperature plasma ionization for ambient mass spectrometry
A. Kiontke, C. Engel, D. Belder, C. Birkemeyer
Anal. Bioanal. Chem. 2018, 410, 5123–5130 - The requirements for low-temperature plasma ionization support miniaturization of the ion source
A. Kiontke, F. Holzer, D. Belder, C. Birkemeyer
Anal. Bioanal. Chem. 2018, 410, 3715–3722 - Surface enhanced Raman spectroscopy in microchip electrophoresis
A. Tycova, R. F. Gerhardt, D. Belder
J. Chromatogr. A 2018, 1541, 39–46 - Catalysis by Metal Nanoparticles in a Plug-in Optofluidic Platform: Redox Reactions of p-Nitrobenzenethiol and p-Aminothiophenol
Z. Zhang, U. Gernert, R. Gerhardt, E.-M. Höhn, D. Belder J. Kneipp
ACS Catal. 2018, 8, 2443–2449 - Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging
S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. A. Robitzki, C. Schneider, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2018, 410, 853–862 - A chip-integrated optical microfluidic pressure sensor
C. Hoera, A. Kiontke, M. Pahl, D. Belder
Sensors and Actuators B: Chemical 2018, 255, 2407–2415
2017
- Microfluidic Free-Flow Electrophoresis Based Solvent Exchanger for Continuously Operating Lab-on-Chip Applications
F. D. Zitzmann, H. G. Jahnke, S. A. Pfeiffer, R. Frank, F. Nitschke, L. Mauritz, B. Abel, D. Belder, A. A. Robitzki,
Anal. Chem. 2017, 89, 13550–13558 - Seamless combination of high pressure chip-HPLC and droplet microfluidics on an integrated microfluidic glass chip
R. Gerhardt, A. J. Peretzki, S. K. Piendl, D. Belder,
Anal. Chem. 2017, 89, 13030–13037 - A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode
F. Zitzmann, H. G. Jahnke, F. Nitschke, A. G. Beck-Sickinger, B. Abel, D. Belder, A. Robitzki,
Lab Chip 2017, 17, 4294–4302 - Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips
S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder,
Anal. Chem. 2017, 89, 6175–6181 - A Highly Stereoselective Synthesis of Tetrahydrofurans
J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder, C. Schneider,
Angew. Chem. Int. Ed. 2017, 24, 6862–6865 - A droplet-chip / mass spectrometry approach to study organic synthesis at nanoliter scale
J. R. Beulig, R. Warias, J. J. Heiland, S. Ohla, K. Zeitler, D. Belder,
Lab Chip 2017, 17, 1996–2002 - Temperature gradient elution and superheated eluents in chip-HPLC
J. J. Heiland, C. Lotter, V. Stein, L. Mauritz, D. Belder,
Anal. Chem. 2017, 89, 3266–3271 - On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
J. J. Heiland , R. Warias , C. Lotter , P. Fuchs , L. Mauritz , K. Zeitler , S. Ohla, D. Belder,
Lab Chip 2017, 17, 76–81 - Microchip HPLC separations monitored simultaneously by coherent anti-Stokes Raman scattering and fluorescence detection
D. Geissler, J. J. Heiland, C. Lotter, D. Belder, Microchim
Acta 2017, 184, 315–321
2016
- Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip
C. Lotter, E. Poehler, J. J. Heiland, L. Mauritz, D. Belder
Lab Chip 2016, 16, 4648–4652 - Evaluation of Pressure Stable Chip-to-Tube Fittings Enabling High-Speed Chip-HPLC with Mass Spectrometric Detection
C. Lotter, J. J. Heiland, V. Stein, M. Klimkait, M. Queisser, D. Belder
Anal. Chem. 2016, 88, 7481–7486 - Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns
C. Dietze, S. Schulze, S. Ohla, K. Gilmore, P. Seeberger, D. Belder
Analyst 2016, 141, 5412–5416 - Chip-based electrochromatography coupled to ESI-MS detection
C. Dietze, C. Hackl, R. Gerhardt, S. Seim, D. Belder
Electrophoresis 2016, 37, 1345–1352 - HPLC-MS with Glass Chips Featuring Monolithically Integrated Electrospray Emitters of Different Geometries
C. Lotter, J. J. Heiland, S. Thurmann, L. Mauritz, D. Belder
Anal. Chem. 2016, 88, 2856–2863 - Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip
K. M. Krone, R. Warias, C. Ritter, A. Li, C. G. Acevedo-Rocha, M. T. Reetz, D. Belder
JACS 2016, 138, 2102–2105 - A chip-integrated highly variable thermal flow rate sensor
C. Hoera, M. M. Skadell, S. A. Pfeiffer, M. Pahl, Z. Shu, E. Beckert, D. Belder
Sensors and Actuators B: Chemical 2016, 225, 42–49
2015
- Rapid prototyping of microfluidic chips for dead-volume-free MS coupling
C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
Anal. Bioanal. Chem. 2015, 407, 8735–8743 - Two-photon excitation in chip electrophoresis enabling label-free fluorescence detection in non-UV transparent full-body polymer chips
D. Geissler, D. Belder
Electrophoresis 2015, 36, 2976–2983 - Fast electrically assisted regeneration of on chip SERS substrates
T. A. Meier, E. Poehler, F. Kemper, O. Pabst, H. G. Jahnke, E. Beckert, A. Robitzki, D. Belder
Lab Chip 2015, 15, 2923–2927 - Chip-Based High-Performance Liquid Chromatography for High-Speed Enantioseparations
S. Thürmann, C. Lotter, J. J. Heiland, B. Chankvetadze, D. Belder
Anal. Chem. 2015, 87, 5568–5576 - Chip-Based Free-Flow Electrophoresis with Integrated Nanospray Mass-Spectrometry
C. Benz, M. Boomhoff, J. Appun, C. Schneider, D. Belder
Angew. Chem. Int. Ed. 2015, 54, 2766–2770 - On-chip monitoring of chemical syntheses in microdroplets via surface-enhanced Raman spectroscopy
T. A. Meier, R. J. Beulig, E. Klinge, M. Fuss, S. Ohla, D. Belder
Chem. Commun. 2015, 51, 8588–8591 - An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors
C. Höra, S. Ohla, Z. Shu, E. Beckert, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2015, 407, 387–396 - Surface modification of PDMS microfluidic devices by controlled sulfuric acid treatment and the application in chip electrophoresis
L. Gitlin, P. Schulze, S. Ohla, H.J. Bongard, D. Belder
Electrophoresis 2015, 36, 449–456
2014
- High-performance liquid chromatography on glass chips using precisely defined porous polymer monoliths as particle retaining elements
S. Thürmann, L. Mauritz, C. Heck, D. Belder
J. Chromatogr. A 2014,1370, 33–39 - Phase-optimized chip-based liquid chromatography
S. Thürmann, D. Belder
Anal. Bioanal. Chem. 2014, 406, 6599–6606 - Rapid Prototyping of Electrochromatography Chips for Improved Two-Photon Excited Fluorescence Detection
C. Hackl , R. Beyreiss , D. Geissler , S. Jezierski, D. Belder
Anal. Chem. 2014, 86, 3773–3779 - A low pressure on-chip injection strategy for high-performance chip-based chromatography
S. Thurmann, A. Dittmar, D. Belder
J. Chromatogr. A 2014, 1340, 59–67 - Improving sensitivity in microchip electrophoresis coupled to ESI-MS/MS on the example of a cardiac drug mixture
F. Schwarzkopf, T. Scholl, S. Ohla, D. Belder
Electrophoresis 2014, 35, 1880–1886
2013
- Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip
S. Jezierski, V. Tehsmer, S. Nagl, D. Belder
Chem. Commun. 2013, 49, 11644–11646 - Label-free fluorescence detection of aromatic compounds in chip electrophoresis applying two photon excitation and time-correlated single photon counting
R. Beyreiss, D. Geißler, S. Ohla, S. Nagl, T. N. Posch, D. Belder
Anal. Chem. 2013, 85, 8150–8157 - Micro flow reactor chips with integrated luminescent chemosensors for spatially resolved on-line chemical reaction monitoring
L. Gitlin, C. Hoera, R. J. Meier, S. Nagl, D. Belder
Lab Chip 2013, 13, 4134–4141 - Protein–protein interaction analysis in single microfluidic droplets using FRET and fluorescence lifetime detection
C. Benz, H. Retzbach, S. Nagl, D. Belder
Lab Chip 2013, 13, 2808–2814 - Towards an integrated device that utilizes adherent cells in a micro-free-flow electrophoresis chip to achieve separation and biosensing
S. Jezierski, A.S. Klein, C. Benz, M. Schaefer, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2013, 5381-–5386 - Microfluidic free-flow electrophoresis chips with an integrated fluorescent sensor layer for real time pH imaging in isoelectric focusing
S. Jezierski , D. Belder, S. Nagl
Chem. Commun. 2013, 49, 904-–906 - Crossing the Border towards Deep UV Time-Resolved Microscopy of Native Fluophores
M. Koenig, S. Tannert, T. Schoenau, K. Lauritsen, F. Koberling, R. Erdmann, R. Beyreiss, S. Nagel, D. Belder
Biophysical Journal 2013, 104, 667A–667A
2012
- Chip-based separation devices coupled to mass spectrometry
S. Ohla, D, Belder
Current Opinion in Chemical Biology 2012, 16, 453–459 - Monitoring on-Chip Pictet-Spengler Reactions by Integrated Analytical Separation and Label-Free Time-Resolved Fluorescence
S. Ohla, R. Beyreiss, S. Fritzsche, P. Glaser, S. Nagl, K. Stockhausen, C. Schneider, D. Belder
Chem. Eur. J. 2012, 18, 1240–1246 - Label-free real-time imaging in microchip free-flow electrophoresis applying high speed deep UV fluorescence scanning
S. Köhler, S. Nagl, S. Fritzsche, D. Belder
Lab Chip 2012, 12, 458–463 - Micro free-flow electrophoresis with injection molded chips
S. Köhler, C. Benz, H. Becker, E. Beckert, V. Beushausen, D. Belder
RSC Adv. 2012, 2, 520–525 - Poly(ethylene glycol)-coated microfluidic devices for chip electrophoresis
M. Schulze, D. Belder
Electrophoresis 2012, 33, 370–378
2011
- Label-free analysis in chip electrophoresis applying deep UV fluorescence lifetime detection
R. Beyreiss, S. Ohla, S. Nagl, D. Belder
Electrophoresis 2011, 32, 3108–3114 - Multistep liquid-phase lithography for fast prototyping of microfluidic free-flow-electrophoresis chips
S. Jezierski, L. Gitlin, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2011, 401, 2651–2656 - Asymmetric Organocatalysis and Analysis on a Single Microfluidic Nanospray Chip
S. Fritzsche, S. Ohla, P. Glaser, D.S. Giera, M. Sickert, C. Schneider, D. Belder
Angew. Chem. Int. Ed. 2011, 50, 9467 –9470 - Microfluidic chips for chirality exploration
S. Nagl, P. Schulze, S. Ohla, R. Beyreiss, L. Gitlin, D. Belder
Anal. Chem. 2011, 83, 3232–3238 - Rapid quantitative determination of ephedra alkaloids in tablet formulations and human urine by microchip electrophoresis
D. Belder*, K. Tolba, S. Nagl
Electrophoresis 2011, 32, 440–447 - Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrometry
S. Ohla, P. Schulze, S. Fritzsche, D. Belder
Anal. Bioanal. Chem. 2011, 399, 1853–1857 - PDMS free-flow electrophoresis chips with integrated partitioning bars for bubble segregation
S. Köhler, C. Weilbeer, S. Howitz, H. Becker, V. Beushausen, D. Belder
Lab Chip 2011, 11, 309–314
2010
- An integrated on-chip sirtuin assay
S. Ohla, R. Beyreiss, G.K E. Scriba, Y. Fan, D. Belder
Electrophoresis 2010, 31, 3263–3267 - Screening in One Sweep using the Slipchip
D. Belder
Angew. Chem. Int. Ed. 2010, 49, 6484–6486 - A New Weakly Basic Amino-Reactive Fluorescent Label for Use in Isoelectric Focusing and Chip Electrophoresis
P. Schulze, M. Link, M. Schulze, S. Thuermann, O.S. Wolfbeis, D. Belder
Electrophoresis 2010, 31, 2749–2753 - Chip electrophoresis with mass spectrometric detection in record speed
S. Fritzsche, P. Hoffmann D. Belder
Lab Chip 2010, 10, 1227–1230
2009
- Spray Performance of Microfluidic Glass Devices with Integrated Pulled Nanoelectrospray Emitters
P. Hoffmann, M. Eschner, S. Fritzsche, D. Belder
Anal. Chem. 2009, 81, 7256–7261 - Progress in microchip enantioseparations
S. Nagl, P. Schulze, M. Ludwig D. Belder
Electrophoresis 2009, 30, 2765–2772 - Towards an Integrated Chemical Circuit
D. Belder
Angew. Chem. Int. Ed. 2009, 48, 3736–3737 - New diode laser-excitable green fluorescent label and its application to detection of bovine serum albumin via microchipelectrophoresis,
M. Link, P. Schulze, D. Belder*, O. Wolfbeis
Microchim. Acta 2009, 166, 183–188 - Label-free fluorescence detection for capillary electrophoresis and microfluidic chip-based techniques,
P. Schulze, D. Belder
Anal. Bioanal. Chem. 2009, 393, 515–525 - Rapid replication of master structures by double casting with PDMS
L. Gitlin, P. Schulze, D. Belder
Lab Chip 2009, 9, 3000–3002
2008
- Impact of laser excitation intensity on deep UV fluorescence detection in microchip electrophoresis
P. Schulze, M. Ludwig, D. Belder
Electrophoresis 2008, 29, 4894–4899
2007
- Fast quantitative determination of diuretic drugs in tablets and human urine by microchip electrophoresis with native fluorescence detection
K. Tolba, D. Belder
Electrophoresis 2007, 28, 2934–2941 - Microfluidic glass chips with an integrated nanospray emitter for coupling to a mass spectrometer
P. Hoffmann, U. Haeusig, P. Schulze, D. Belder
Angew. Chem. Int. Ed. 2007, 46, 4913–4916 - Two-photon excited fluorescence detection at 420 nm for label-free detection of small aromatics and proteins in microchip electrophoresis
P. Schulze, M. Schuettpelz, M. Sauer, D. Belder
Lab Chip 2007, 7, 1841–1844
2006
- Coating of powder-blasted channels for high-performance microchip electrophoresis
D. Belder, F. Kohler, M. Ludwig, K. Tolba, N. Piehl
Electrophoresis 2006, 27, 3277–3283 - Integrating chemical synthesis and analysis on a chip
D. Belder
Anal. Bioanal. Chem. 2006, 385, 416–418 - Enantioselective catalysis and analysis on a chip
D. Belder, M. Ludwig, L.W. Wang, M.T. Reetz
Angew. Chem. Int. Ed. 2006, 45, 2463–2466
2005
- Deep UV laser-induced fluorescence detection of unlabeled drugs and proteins in microchip electrophoresis
P. Schulze, M. Ludwig, F. Kohler, D. Belder
Analytical Chemistry 2005, 77, 1325–1329 - Microfluidics with droplets
D. Belder
Angew. Chem. Int. Ed. 2005, 44, 3521–3522
2004
- Subsecond chiral separations on a microchip
N. Piehl, M. Ludwig, D. Belder
Electrophoresis 2004, 25, 3848–3852 - Separation of fluorescein isothiocyanate-labeled amines by microchip electrophoresis in uncoated and polyvinyl alcohol-coated glass chips using water and dimethyl sulfoxide as solvents of background electrolyte
S.J.O. Varjo, M. Ludwig, D. Belder, M.L. Riekkola
Electrophoresis 2004, 25, 1901–1906
2003
- Surface modification in microchip electrophoresis
D. Belder, M. Ludwig
Electrophoresis 2003, 24, 3595–3606 - High-speed chiral separations on a microchip with UV detection
M. Ludwig, F. Kohler, D. Belder
Electrophoresis 2003, 24, 3233–3238 - Microchip electrophoresis for chiral separations
D. Belder, M. Ludwig
Electrophoresis 2003, 24, 2422–2430 - Coated microfluidic devices for improved chiral separations in microchip electrophoresis
M. Ludwig, D. Belder
Electrophoresis 2003, 24, 2481–2486
2002
- Poly(vinyl alcohol)-coated microfluidic devices for high-performance microchip electrophoresis
D. Belder, A. Deege, F. Kohler, M. Ludwig
Electrophoresis 2002, 23, 3567–3573 - Design and performance of a microchip electrophoresis instrument with sensitive variable-wavelength fluorescence detection
D. Belder, A. Deege, M. Maass, M. Ludwig
Electrophoresis 2002, 23, 2355–2361
- Modular Chip-Based nanoSFC–MS for Ultrafast Separations
C. Weise, M. Schirmer, M. Polack, A. Korell, H. Westphal, J. Schwieger, R. Warias, S., D. Belder
Anal. Chem. 2024, 96, 34, 13888–13896 - Mass spectrometry coupling of chip-based supercritical fluid chromatography enabled by make-up flow-assisted backpressure regulation
C. Weise, J. Fischer, D. Belder
Anal Bioanal Chem. 2024, 416, 4447–4456 - Exploring Defect-Engineered Metal–Organic Frameworks with 1,2,4-Triazolyl Isophthalate and Benzoate Linkers
S. Chetry, M. F. Lukman, V. Bon, R. Warias, D. Fuhrmann, J. Möllmer, D. Belder, C. S. Gopinath, S. Kaskel, A. Pöppl, H. Krautscheid
Inorg. Chem. 2024, 63, 23, 10843–10853 - Online‐Monitoring of the Enantiomeric Ratio in Microfluidic Chip Reactors Using Chiral Selector Ion Vibrational Spectroscopy
S. Schmahl, F. Horn, J. Jin, H. Westphal, D. Belder, K. R. Asmis
ChemPhysChem. 2024, 25, e202300975 - An LSC approach for tritium determination in gaseous mixtures optimized with respect to handling, reaction parameters and miniaturization towards microfluidic analysis
A. Becker, H. Lippold, J. P. Bäcker, D. Belder, C. Fischer
Radiochimica Acta 2024, 112, 231–237 - High-temperature ultrafast ChipHPLC-MS
C. Weise, H. Westphal, R. Warias, D.Belder
Anal. Bioanal. Chem. 2024, 416, 1023–1031 - Coupling of droplet-on-demand microfluidcs with ESI/MS to study single-cell catalysis
M. van der Loh, M. Schiffmann, M. Polack, K. Wink, D. Belder
RSC Adv. 2024, 14, 25337–25346 - Integration of a recyclable silver substrate for in situ surface-enhanced Raman spectroscopy in digital microfluidics
S. Fehse, A. Das, D. Belder
Chem. Commun. 2024, 60, 8252–8255 - Development of an automated platform for monitoring microfluidic reactors through multi-reactor integration and online (chip-) LC/MS-detection
H. Westphal, S. Schmidt, S. Lama, M. Polack, C. Weise, T. Oestereich, R. Warias, T. Gulder, D. Belder
React. Chem. Eng. 2024, 9, 1739–1750
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scMAR-Seq: a novel workflow for targeted single-cell genomics of microorganisms using radioactive labeling
H. Y. Lo, K. Wink, H. Nitz, M. Kästner, D. Belder, J. A. Müller, A. K. Kaster
mSystems 2023, DOI: https://doi.org/10.1128/msystems.00998-23 -
A monolithic microfluidic probe for ambient mass spectrometry imaging of biological tissues
L. Jiang, M. Polack, X. Li, M. Yang, D. Belder, J. Laskin
Lab Chip 2023, DOI: 10.1039/d3lc00637a - Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/MS
C. Thoben, N. T. Hartner, M. Hitzemann, C. R. Raddatz, M. Eckermann, D. Belder, S. Zimmermann
J. Am. Soc. Mass Spectrom. 2023, 34, 5, 857–868
- Coupling microchip pressure regulators with chipHPLC as a step toward fully portable analysis system
K. Svensson, C. Weise, H. Westphal, S. Södergren, D. Belder, K. Hjort
Sensors & Actuators: B Chemical 2023, 385, 133732
- Surface-Enhanced Raman Spectroscopic Probing in Digital Microfluidics through a Microspray Hole
A. Das, S. Fehse, M. Polack, R. Panneerselvam, D. Belder
Anal. Chem. 2023, 95, 2, 1262–1272
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Integration of Impedimetric Sensors for In Situ Electrochemical Impedance Spectroscopy in Free-Flow Electrophoresis Applications in Lab-on-Chip Systems
T. Haensch, F. D. Zitzmann, H. G. Jahnke, M. E. Blaha, E. Paternoga, K. Zeitler, D. Belder, A. A. Robitzki
ACS Sens. 2022, 7, 12, 3906–3914 -
Analysis of double-emulsion droplets with ESI mass spectrometry for monitoring lipase-catalyzed ester hydrolysis at nanoliter scale
L. Heiligenthal, M. van der Loh, M. Polack, M. E. Blaha, S. Moschütz, A. Keim, N. Sträter, D. Belder
Anal. Bioanal. Chem. 2022, 414, 6977–6987 -
An integrated resource-efficient microfluidic device for parallelised studies of immobilised chiral catalysts in continuous flow via miniaturized LC/MS-analysis
H. Westphal, R. Warias, C. Weise, D. Ragno, H. Becker, M. Spanka, A. Massi, R. Gläser, C. Schneider, D. Belder
React. Chem. Eng. 2022, 7, 1936–1944 -
On-the-Fly Mass Spectrometry in Digital Microfluidics Enabled by a Microspray Hole: Toward Multidimensional Reaction Monitoring in Automated Synthesis Platform
A. Das, C. Weise, M. Polack, R. D. Urban, B. Krafft, S. Hasan, H. Westphal, R. Warias, S. Schmidt, T. Gulder, D. Belder
J. Am. Chem. Soc. 2022, 144, 23, 10353–10360 -
Quantification of Biocatalytic Transformations by Single Microbial Cells Enabled by Tailored Integration of Droplet Microfluidics and Mass Spectrometry
K. Wink, M. van der Loh, N. Hartner, M. Polack, C. Dusny, A. Schmid, D. Belder
Angew. Chem. Int. Ed. 2022, 61, e202204098 -
Fluorescence lifetime activated droplet sorting (FLADS) for label-free sorting of Synechocystis sp. PCC6803
M. E. Blaha, S. Hasan, C. Dusny, D. Belder
Lab Chip, 2022, 22, 1604–1614 - Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?
R. Panneerselvam, H. Sadat, E. M. Höhn, A. Das, H. Noothalapati, D. Belder
Lab Chip 2022, 22, 665–682 - Multielectrode biosensor chip for spatial resolution screening of 3D cell models based on microcavity arrays
F. D. Zitzmann, S. Schmidt, M. Naumann, D. Belder, H. G. Jahnke, A. A. Robitzki
Biosensors and Bioelectronics, 2022, 202, 114010 - Two-photon fluorescence lifetime for label-free microfluidic droplet sorting
S. Hasan, M. E. Blaha, S. K. Piendl, A. Das, D. Geissler, D. Belder
Anal. Bioanal. Chem., 2022, 414, 721–730
- Coupling Droplet Microfluidics with Ion Mobility Spectrometry for Monitoring Chemical Conversions at Nanoliter Scale
N. T. Hartner, K. Wink, C. R. Raddatz, C. Thoben, M. Schirmer, S. Zimmermann, D. Belder
Anal. Chem. 2021, 93, 40, 13615–13623 - Unveiling Organocatalysts Action–Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology
H. Westphal, R. Warias, H. Becker, M. Spanka, D. Ragno, R. Gläser, C. Schneider, A. Massi, Prof. D. Belder
ChemCatChem 2021, 13, 5089-5096 - Integration of Segmented Microflow Chemistry and Online HPLC/MS Analysis on a Microfluidic Chip System Enabling Enantioselective Analyses at the Nanoliter Scale
S. K. Piendl, T. Schönfelder, M. Polack, L. Weigelt, T. van der Zwaag, T. Teutenberg, E. Beckert, D. Belder
Lab Chip 2021, DOI: 10.1039/D1LC00078K - On-chip Mass Spectrometric Analysis in Non-polar Solvents by Liquid Beam Infrared Matrix-Assisted Laser Dispersion/Ionization
R. D. Urban, T. G. Fischer, A. Charvat, K. Wink, B. Krafft, S. Ohla, K. Zeitler, B. Abel, D. Belder
Anal. Bioanal. Chem. 2021, in press, doi: 10.1007/s00216-020-03115-4 - Microfluidic device for concentration and SERS‐based detection of bacteria in drinking water
B. Krafft, A. Tycova, R. D. Urban, C. Dusny, D. Belder
Electrophoresis 2021, 42, 86–94
- On-Line Coupling of Chip-Electrochromatography and Ion Mobility Spectrometry
N. T. Hartner, C. R. Raddatz, C. Thoben, S. K. Piendl, S. Zimmermann, D. Belder
Anal. Chem. 2020, 92, 15129–15136 - How electrospray potentials can disrupt droplet microfluidics and how to prevent this
A. J. Peretzki, S. Schmidt, E. Flachowsky, A. Das, R. F. Gerhardt, D. Belder
Lab Chip, 2020, 20, 4456–4465 - In situ monitoring of photocatalyzed isomerization reactions on a microchip flow reactor by IR-MALDI ion mobility spectrometry
C. Prüfert, R. D. Urban, T. G. Fischer, J. Villatoro., D. Riebe., T. Beitz., D. Belder, K. Zeitler, H. G. Löhmannsröben
Anal. Bioanal. Chem. 2020, 412, 7899–7911 - Conversion Efficiencies of a Few Living Microbial Cells Detected at a High Throughput by Droplet-Based ESI-MS
M. Schirmer, K. Wink, S. Ohla, D. Belder, A. Schmid, C. Dusny
Anal. Chem. 2020, 92, 15, 10700–10708 - A visible‐light‐powered polymerization method for the immobilization of enantioselective organocatalysts into microreactors
R. Warias, D. Ragno, A. Massi, D. Belder
Chem. Eur. J. 2020, 26, 13152–13156 - Multiple Heart-Cutting Two-Dimensional Chip-HPLC Combined with Deep-UV Fluorescence and Mass Spectrometric Detection
S. K. Piendl, D. Geissler, L. Weigelt, D. Belder
Anal. Chem. 2020, 92, 3795–3803 - Unravelling the Configuration of Transient ortho-Quinone Methides by Combining Microfluidics with Gas Phase Vibrational Spectroscopy
M. Mayer , M. Pahl , M. Spanka , M. Grellmann , M. Sickert , C. Schneider , K. R. Asmis, D. Belder
Phys. Chem. Chem. Phys. 2020, 22, 4610–4616 - A microfluidic device enabling surface-enhanced Raman spectroscopy at chip-integrated multifunctional nanoporous membranes
B. Krafft, R. P. Selvam, D. Geissler, D. Belder
Anal. Bioanal. Chem. 2020, 412, 267–277 - On-chip integration of normal phase high-performance liquid chromatography and droplet microfluidics introducing ethylene glycol as polar continuous phase for the compartmentalization of n-heptane eluents
A. J. Peretzki, D. Belder
J. Chromatogr. A 2020, 1612, 460653
- Raman Spectroscopic Detection in Continuous Micro-Flow Using a Chip-Integrated Silver Electrode as Electrically Regenerable SERS Substrate
E. M. Höhn, R. Panneerselvam, A. Das, D. Belder
Anal. Chem. 2019, 91, 9844–9854 - 2D in Seconds: Coupling of Chip-HPLC with Ion Mobility Spectrometry
S. K. Piendl, C. R. Raddatz, N. T. Hartner, C. Thoben, R. Warias, S. Zimmermann, D. Belder
Anal. Chem. 2019, 91, 7613–7620 - Non-aqueous micro free-flow electrophoresis for continuous separation of reaction mixtures in organic media
B. M. Rudisch, S. A. Pfeiffer, D. Geissler, E. Speckmeier, A. A. Robitzki, K. Zeitler, D. Belder
Anal. Chem. 2019, 91, 6689–6694 - Supercritical fluid chromatography on-chip with two-photon excited fluorescence detection for high-speed chiral separations
J. J. Heiland, D. Geissler, S. K. Piendl, R. Warias, D. Belder
Anal. Chem. 2019, 91, 6134–6140 - Large‐Ring Cyclodextrins as Chiral Selectors for Enantiomeric Pharmaceuticals
C. Sonnendecker, S. Th[1]ürmann, C. Przybylski, F. D. Zitzmann, N. Heinke, Y. Krauke, K. Monks, A. A. Robitzki, D. Belder, W. Zimmermann
Angew. Chem. Int. Ed. 2019, 58, 6411–6414 - Joining Microfluidics with Infrared Photodissociation: Online Monitoring of Isomeric Flow-Reaction Intermediates
M. Pahl, M. Mayer, M. Schneider, D. Belder, K. R. Asmis
Anal Chem. 2019, 91, 3199–3203 - Fluorescence lifetime-activated droplet sorting in microfluidic chip systems
S. Hasan, D. Geissler, K. Wink, A. Hagen, J. J. Heiland, D. Belder
Lab Chip 2019, 19, 403–409
- An integrated lab‐on‐a‐chip approach to study heterogeneous enantioselective catalysts at the microscale
R. Warias, A. Zaghi, J. J. Heiland, S. K. Piendl, K. Gilmore, P. H. Seeberger, A. Massi, D. Belder
ChemCatChem. 2018, 10, 5382–5385 - An integrated chip-mass spectrometry and epifluorescence approach for online monitoring of bioactive metabolites from incubated Actinobacteria in picoliter droplets
K. Wink, L. Mahler, J. R. Beulig, S. K. Piendl, M. Roth, D. Belder
Anal. Bioanal. Chem. 2018, 410, 7679–7687 - Sheathless coupling of microchip electrophoresis to ESI-MS utilising an integrated photo polymerised membrane for electric contacting
T. Scholl, C. Dietze, M. Schmidt, S. Ohla, D. Belder
Anal. Bioanal. Chem. 2018, 410, 5741–5750 - Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria
L. Mahler, K. Wink, R. J. Beulig, K. Scherlach, M. Tovar, E. Zang, K. Martin, C. Hertweck, D. Belder, M. Roth
Scientific reports 2018, 8, 13087 - Analyte and matrix evaporability–key players of low-temperature plasma ionization for ambient mass spectrometry
A. Kiontke, C. Engel, D. Belder, C. Birkemeyer
Anal. Bioanal. Chem. 2018, 410, 5123–5130 - The requirements for low-temperature plasma ionization support miniaturization of the ion source
A. Kiontke, F. Holzer, D. Belder, C. Birkemeyer
Anal. Bioanal. Chem. 2018, 410, 3715–3722 - Surface enhanced Raman spectroscopy in microchip electrophoresis
A. Tycova, R. F. Gerhardt, D. Belder
J. Chromatogr. A 2018, 1541, 39–46 - Catalysis by Metal Nanoparticles in a Plug-in Optofluidic Platform: Redox Reactions of p-Nitrobenzenethiol and p-Aminothiophenol
Z. Zhang, U. Gernert, R. Gerhardt, E.-M. Höhn, D. Belder J. Kneipp
ACS Catal. 2018, 8, 2443–2449 - Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging
S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. A. Robitzki, C. Schneider, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2018, 410, 853–862 - A chip-integrated optical microfluidic pressure sensor
C. Hoera, A. Kiontke, M. Pahl, D. Belder
Sensors and Actuators B: Chemical 2018, 255, 2407–2415
- Microfluidic Free-Flow Electrophoresis Based Solvent Exchanger for Continuously Operating Lab-on-Chip Applications
F. D. Zitzmann, H. G. Jahnke, S. A. Pfeiffer, R. Frank, F. Nitschke, L. Mauritz, B. Abel, D. Belder, A. A. Robitzki,
Anal. Chem. 2017, 89, 13550–13558 - Seamless combination of high pressure chip-HPLC and droplet microfluidics on an integrated microfluidic glass chip
R. Gerhardt, A. J. Peretzki, S. K. Piendl, D. Belder,
Anal. Chem. 2017, 89, 13030–13037 - A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode
F. Zitzmann, H. G. Jahnke, F. Nitschke, A. G. Beck-Sickinger, B. Abel, D. Belder, A. Robitzki,
Lab Chip 2017, 17, 4294–4302 - Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips
S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder,
Anal. Chem. 2017, 89, 6175–6181 - A Highly Stereoselective Synthesis of Tetrahydrofurans
J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder, C. Schneider,
Angew. Chem. Int. Ed. 2017, 24, 6862–6865 - A droplet-chip / mass spectrometry approach to study organic synthesis at nanoliter scale
J. R. Beulig, R. Warias, J. J. Heiland, S. Ohla, K. Zeitler, D. Belder,
Lab Chip 2017, 17, 1996–2002 - Temperature gradient elution and superheated eluents in chip-HPLC
J. J. Heiland, C. Lotter, V. Stein, L. Mauritz, D. Belder,
Anal. Chem. 2017, 89, 3266–3271 - On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
J. J. Heiland , R. Warias , C. Lotter , P. Fuchs , L. Mauritz , K. Zeitler , S. Ohla, D. Belder,
Lab Chip 2017, 17, 76–81 - Microchip HPLC separations monitored simultaneously by coherent anti-Stokes Raman scattering and fluorescence detection
D. Geissler, J. J. Heiland, C. Lotter, D. Belder, Microchim
Acta 2017, 184, 315–321
- Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip
C. Lotter, E. Poehler, J. J. Heiland, L. Mauritz, D. Belder
Lab Chip 2016, 16, 4648–4652 - Evaluation of Pressure Stable Chip-to-Tube Fittings Enabling High-Speed Chip-HPLC with Mass Spectrometric Detection
C. Lotter, J. J. Heiland, V. Stein, M. Klimkait, M. Queisser
D. Belder, Anal. Chem. 2016, 88, 7481–7486 - Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns
C. Dietze, S. Schulze, S. Ohla, K. Gilmore, P. Seeberger, D. Belder
Analyst 2016, 141, 5412–5416 - Chip-based electrochromatography coupled to ESI-MS detection
C. Dietze, C. Hackl, R. Gerhardt, S. Seim, D. Belder
Electrophoresis 2016, 37, 1345–1352 - HPLC-MS with Glass Chips Featuring Monolithically Integrated Electrospray Emitters of Different Geometries
C. Lotter, J. J. Heiland, S. Thurmann, L. Mauritz, D. Belder
Anal. Chem. 2016, 88, 2856–2863 - Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip
K. M. Krone, R. Warias, C. Ritter, A. Li, C. G. Acevedo-Rocha, M. T. Reetz, D. Belder
JACS 2016, 138, 2102–2105 - A chip-integrated highly variable thermal flow rate sensor
C. Hoera, M. M. Skadell, S. A. Pfeiffer, M. Pahl, Z. Shu, E. Beckert, D. Belder
Sensors and Actuators B: Chemical 2016, 225, 42–49
- Rapid prototyping of microfluidic chips for dead-volume-free MS coupling
C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
Anal. Bioanal. Chem. 2015, 407, 8735–8743 - Two-photon excitation in chip electrophoresis enabling label-free fluorescence detection in non-UV transparent full-body polymer chips
D. Geissler, D. Belder
Electrophoresis 2015, 36, 2976–2983 - Fast electrically assisted regeneration of on chip SERS substrates
T. A. Meier, E. Poehler, F. Kemper, O. Pabst, H. G. Jahnke, E. Beckert, A. Robitzki, D. Belder
Lab Chip 2015, 15, 2923–2927 - Chip-Based High-Performance Liquid Chromatography for High-Speed Enantioseparations
S. Thürmann, C. Lotter, J. J. Heiland, B. Chankvetadze, D. Belder
Anal. Chem. 2015, 87, 5568–5576 - Chip-Based Free-Flow Electrophoresis with Integrated Nanospray Mass-Spectrometry
C. Benz, M. Boomhoff, J. Appun, C. Schneider, D. Belder
Angew. Chem. Int. Ed. 2015, 54, 2766–2770 - On-chip monitoring of chemical syntheses in microdroplets via surface-enhanced Raman spectroscopy
T. A. Meier, R. J. Beulig, E. Klinge, M. Fuss, S. Ohla, D. Belder
Chem. Commun. 2015, 51, 8588–8591 - An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors
C. Höra, S. Ohla, Z. Shu, E. Beckert, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2015, 407, 387–396 - Surface modification of PDMS microfluidic devices by controlled sulfuric acid treatment and the application in chip electrophoresis
L. Gitlin, P. Schulze, S. Ohla, H.J. Bongard, D. Belder
Electrophoresis 2015, 36, 449–456
- High-performance liquid chromatography on glass chips using precisely defined porous polymer monoliths as particle retaining elements
S. Thürmann, L. Mauritz, C. Heck, D. Belder
J. Chromatogr. A 2014,1370, 33–39 - Phase-optimized chip-based liquid chromatography
S. Thürmann, D. Belder
Anal. Bioanal. Chem. 2014, 406, 6599–6606 - Rapid Prototyping of Electrochromatography Chips for Improved Two-Photon Excited Fluorescence Detection
C. Hackl , R. Beyreiss , D. Geissler , S. Jezierski, D. Belder
Anal. Chem. 2014, 86, 3773–3779 - A low pressure on-chip injection strategy for high-performance chip-based chromatography
S. Thurmann, A. Dittmar, D. Belder
J. Chromatogr. A 2014, 1340, 59–67 - Improving sensitivity in microchip electrophoresis coupled to ESI-MS/MS on the example of a cardiac drug mixture
F. Schwarzkopf, T. Scholl, S. Ohla, D. Belder
Electrophoresis 2014, 35, 1880–1886
- Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip
S. Jezierski, V. Tehsmer, S. Nagl, D. Belder
Chem. Commun. 2013, 49, 11644–11646 - Label-free fluorescence detection of aromatic compounds in chip electrophoresis applying two photon excitation and time-correlated single photon counting
R. Beyreiss, D. Geißler, S. Ohla, S. Nagl, T. N. Posch, D. Belder
Anal. Chem. 2013, 85, 8150–8157 - Micro flow reactor chips with integrated luminescent chemosensors for spatially resolved on-line chemical reaction monitoring
L. Gitlin, C. Hoera, R. J. Meier, S. Nagl, D. Belder
Lab Chip 2013, 13, 4134–4141 - Protein–protein interaction analysis in single microfluidic droplets using FRET and fluorescence lifetime detection
C. Benz, H. Retzbach, S. Nagl, D. Belder
Lab Chip 2013, 13, 2808–2814 - Towards an integrated device that utilizes adherent cells in a micro-free-flow electrophoresis chip to achieve separation and biosensing
S. Jezierski, A.S. Klein, C. Benz, M. Schaefer, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2013, 5381-–5386 - Microfluidic free-flow electrophoresis chips with an integrated fluorescent sensor layer for real time pH imaging in isoelectric focusing
S. Jezierski , D. Belder, S. Nagl
Chem. Commun. 2013, 49, 904-–906 - Crossing the Border towards Deep UV Time-Resolved Microscopy of Native Fluophores
M. Koenig, S. Tannert, T. Schoenau, K. Lauritsen, F. Koberling, R. Erdmann, R. Beyreiss, S. Nagel, D. Belder
Biophysical Journal 2013, 104, 667A–667A
- Chip-based separation devices coupled to mass spectrometry
S. Ohla, D, Belder
Current Opinion in Chemical Biology 2012, 16, 453–459 - Monitoring on-Chip Pictet-Spengler Reactions by Integrated Analytical Separation and Label-Free Time-Resolved Fluorescence
S. Ohla, R. Beyreiss, S. Fritzsche, P. Glaser, S. Nagl, K. Stockhausen, C. Schneider, D. Belder
Chem. Eur. J. 2012, 18, 1240–1246 - Label-free real-time imaging in microchip free-flow electrophoresis applying high speed deep UV fluorescence scanning
S. Köhler, S. Nagl, S. Fritzsche, D. Belder
Lab Chip 2012, 12, 458–463 - Micro free-flow electrophoresis with injection molded chips
S. Köhler, C. Benz, H. Becker, E. Beckert, V. Beushausen, D. Belder
RSC Adv. 2012, 2, 520–525 - Poly(ethylene glycol)-coated microfluidic devices for chip electrophoresis
M. Schulze, D. Belder
Electrophoresis 2012, 33, 370–378
- Label-free analysis in chip electrophoresis applying deep UV fluorescence lifetime detection
R. Beyreiss, S. Ohla, S. Nagl, D. Belder
Electrophoresis 2011, 32, 3108–3114 - Multistep liquid-phase lithography for fast prototyping of microfluidic free-flow-electrophoresis chips
S. Jezierski, L. Gitlin, S. Nagl, D. Belder
Anal. Bioanal. Chem. 2011, 401, 2651–2656 - Asymmetric Organocatalysis and Analysis on a Single Microfluidic Nanospray Chip
S. Fritzsche, S. Ohla, P. Glaser, D.S. Giera, M. Sickert, C. Schneider, D. Belder
Angew. Chem. Int. Ed. 2011, 50, 9467 –9470 - Microfluidic chips for chirality exploration
S. Nagl, P. Schulze, S. Ohla, R. Beyreiss, L. Gitlin, D. Belder
Anal. Chem. 2011, 83, 3232–3238 - Rapid quantitative determination of ephedra alkaloids in tablet formulations and human urine by microchip electrophoresis
D. Belder*, K. Tolba, S. Nagl
Electrophoresis 2011, 32, 440–447 - Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrometry
S. Ohla, P. Schulze, S. Fritzsche, D. Belder
Anal. Bioanal. Chem. 2011, 399, 1853–1857 - PDMS free-flow electrophoresis chips with integrated partitioning bars for bubble segregation
S. Köhler, C. Weilbeer, S. Howitz, H. Becker, V. Beushausen, D. Belder
Lab Chip 2011, 11, 309–314
- An integrated on-chip sirtuin assay
S. Ohla, R. Beyreiss, G.K E. Scriba, Y. Fan, D. Belder
Electrophoresis 2010, 31, 3263–3267 - Screening in One Sweep using the Slipchip
D. Belder
Angew. Chem. Int. Ed. 2010, 49, 6484–6486 - A New Weakly Basic Amino-Reactive Fluorescent Label for Use in Isoelectric Focusing and Chip Electrophoresis
P. Schulze, M. Link, M. Schulze, S. Thuermann, O.S. Wolfbeis, D. Belder
Electrophoresis 2010, 31, 2749–2753 - Chip electrophoresis with mass spectrometric detection in record speed
S. Fritzsche, P. Hoffmann D. Belder
Lab Chip 2010, 10, 1227–1230
2009
- Spray Performance of Microfluidic Glass Devices with Integrated Pulled Nanoelectrospray Emitters
P. Hoffmann, M. Eschner, S. Fritzsche, D. Belder
Anal. Chem. 2009, 81, 7256–7261 - Progress in microchip enantioseparations
S. Nagl, P. Schulze, M. Ludwig D. Belder
Electrophoresis 2009, 30, 2765–2772 - Towards an Integrated Chemical Circuit
D. Belder
Angew. Chem. Int. Ed. 2009, 48, 3736–3737 - New diode laser-excitable green fluorescent label and its application to detection of bovine serum albumin via microchipelectrophoresis,
M. Link, P. Schulze, D. Belder*, O. Wolfbeis
Microchim. Acta 2009, 166, 183–188 - Label-free fluorescence detection for capillary electrophoresis and microfluidic chip-based techniques,
P. Schulze, D. Belder
Anal. Bioanal. Chem. 2009, 393, 515–525 - Rapid replication of master structures by double casting with PDMS
L. Gitlin, P. Schulze, D. Belder
Lab Chip 2009, 9, 3000–3002
2008
- Impact of laser excitation intensity on deep UV fluorescence detection in microchip electrophoresis
P. Schulze, M. Ludwig, D. Belder
Electrophoresis 2008, 29, 4894–4899
2007
- Fast quantitative determination of diuretic drugs in tablets and human urine by microchip electrophoresis with native fluorescence detection
K. Tolba, D. Belder
Electrophoresis 2007, 28, 2934–2941 - Microfluidic glass chips with an integrated nanospray emitter for coupling to a mass spectrometer
P. Hoffmann, U. Haeusig, P. Schulze, D. Belder
Angew. Chem. Int. Ed. 2007, 46, 4913–4916 - Two-photon excited fluorescence detection at 420 nm for label-free detection of small aromatics and proteins in microchip electrophoresis
P. Schulze, M. Schuettpelz, M. Sauer, D. Belder
Lab Chip 2007, 7, 1841–1844
2006
- Coating of powder-blasted channels for high-performance microchip electrophoresis
D. Belder, F. Kohler, M. Ludwig, K. Tolba, N. Piehl
Electrophoresis 2006, 27, 3277–3283 - Integrating chemical synthesis and analysis on a chip
D. Belder
Anal. Bioanal. Chem. 2006, 385, 416–418 - Enantioselective catalysis and analysis on a chip
D. Belder, M. Ludwig, L.W. Wang, M.T. Reetz
Angew. Chem. Int. Ed. 2006, 45, 2463–2466
2005
- Deep UV laser-induced fluorescence detection of unlabeled drugs and proteins in microchip electrophoresis
P. Schulze, M. Ludwig, F. Kohler, D. Belder
Analytical Chemistry 2005, 77, 1325–1329 - Microfluidics with droplets
D. Belder
Angew. Chem. Int. Ed. 2005, 44, 3521–3522
2004
- Subsecond chiral separations on a microchip
N. Piehl, M. Ludwig, D. Belder
Electrophoresis 2004, 25, 3848–3852 - Separation of fluorescein isothiocyanate-labeled amines by microchip electrophoresis in uncoated and polyvinyl alcohol-coated glass chips using water and dimethyl sulfoxide as solvents of background electrolyte
S.J.O. Varjo, M. Ludwig, D. Belder, M.L. Riekkola
Electrophoresis 2004, 25, 1901–1906
2003
- Surface modification in microchip electrophoresis
D. Belder, M. Ludwig
Electrophoresis 2003, 24, 3595–3606 - High-speed chiral separations on a microchip with UV detection
M. Ludwig, F. Kohler, D. Belder
Electrophoresis 2003, 24, 3233–3238 - Microchip electrophoresis for chiral separations
D. Belder, M. Ludwig
Electrophoresis 2003, 24, 2422–2430 - Coated microfluidic devices for improved chiral separations in microchip electrophoresis
M. Ludwig, D. Belder
Electrophoresis 2003, 24, 2481–2486
2002
- Poly(vinyl alcohol)-coated microfluidic devices for high-performance microchip electrophoresis
D. Belder, A. Deege, F. Kohler, M. Ludwig
Electrophoresis 2002, 23, 3567–3573 - Design and performance of a microchip electrophoresis instrument with sensitive variable-wavelength fluorescence detection
D. Belder, A. Deege, M. Maass, M. Ludwig
Electrophoresis 2002, 23, 2355–2361
Weitere Referenzen
- Trendbericht Analytische Chemie II: Trenntechniken und Elektroanalytik
M. Vogel, W. Engewald, K. Dettmer‐Wilde, O. J. Schmitz, M. Sperling, C. G. Huber, C. Regl, T. Berger, S. Piendl, D. Belder, F.‐M. Matysik, Nachrichten aus Chemie und Technik, 2020, 68, 48–53. - Analytische Chemie 2014/2015
B. Hagenhoff, U. Karst, S. Ohla, S. Nagl, D. Belder, T. Teutenberg, H. Hayen, M. Sperling, M. Maiwald, C. Huber, M. Vogel, Nachrichten aus der Chemie, 2016, 64, 497 - 508. - Kleiner, schneller, vielseitiger
Detlev Belder, Separation, 2006, GIT–Verlag. - Der Traum vom Westentaschenlabor
Detlev Belder, HighChem, 2006, Hrsg. GDCH, 90–91. - Microfluidics: record speed for the fastest separation
Detlev Belder, Analytica Pro, 2006, 12–14. - Auf dem Weg zum Chip–Labor
Detlev Belder, Jahrbuch der MPG, 2005, 321–325. - Vom DNA–Sequencer zum HTS–System für die Organische Synthese
Detlev Belder, Nachrichten aus Chemie und Technik, 2003, 51, 757–759.
- Chiral separations in microfluidic devices
Detlev Belder, in Chiral Analysis, Busch Busch (Ed.), chapter 9, Elsevier, in press 2006. - Catalysis on a chip
Detlev Belder, in Catalysis from A to Z, Boy Cornils (Ed.), in press 2006.
- „Mikrofluidische Chips mit immanenten hydrophilen Oberflächen“
D. Belder, M. Ludwig (Studiengesellschaft Kohle mbH), deutsche Patentanmeldung, 2004. - „High–Throughput Verfahren zur Bestimmung der Enantiomerenreinheit von chiralen Verbindungen“
M.T. Reetz, K.M. Kühling, A. Deege H. Hinrichs, D. Belder (Studiengesellschaft Kohle mbH), WO0218922, 2000. - „Beschichtungen mit quervernetzten Polymeren“
D. Belder, H. Husmann, (Studiengesellschaft Kohle mbH) DE 19938002, 1999.
- Minilabore ermöglichen neue Einblicke
Ilka Ottleben, LABORPRAXIS, März 2016. - Chemische Prozesse im Mikromaßstab untersuchen
Marc Platthaus, LABORPRAXIS, Juli 2015. - Diverting free-flowing streams: Linking free-flow electrophoresis with ESI-MS
Jon Evans, separationsNOW, Februar 2015. - Mikrofluidik-Chip ermöglicht komplexe chemische Prozesse auf kleinstem Raum
Analytik News, Februar 2015. - Leipziger Mikrolabor-Chip für schnellere Arzneientwicklung
Heiko Weckbrodt, Oiger - Neues aus Wirtschaft und Forschung, Februar 2015. - Gute Nachricht des Tages: Chemielabor auf Chipgröße geschrumpft
n-tv, September 2011. - Weltrekord: Leipziger Forscher trennen chemische Substanzen am schnellsten
Leipziger Volkszeitung, Juni 2010. - Further integration of micro fluidics and mass spec
Michael Gross, Chemistry World, May 2007. - All together now
Steve Haswell, Nature 2006, 441, 705. - Chiral catalysis on a Chip
Michael Gross, Chemistry World, February 2006. - Chirale Katalyse und Analyse auf einem Chip vereint
Michael Groß, Chem. Unserer Zeit 2006, 40, 91. - Chips mit Grips
Roland Wengenmayr, Max Planck Forschung 4/2004